Biologics

Arthrosurface now offers multiple solutions to replace standard microfracture procedures. NanoFx® is a Smaller, Deeper and Better solution for cartilage defect repair than your average microfracture procedure while the Nanofactor™ Flow and Membrane are regenerative therapies which use amniotic tissue grafts.

knee injuriesknee joint

The NanoFx® (Nanofracture) system consists of a reusable Hand Instrument and a single use disposable PleuriStik™ to perform a marrow stimulation procedure for the treatment of  localized articular cartilage defects or to augment soft tissue repairs. The 1mm PleuriStik™ disrupts significantly less surface area than a standard microfracture technique to reduce damage to the subchondral bone plate. The idea is to initiate a cartilage healing response, not a bone healing response, which is why it is important to not disrupt the bone plate. It penetrates down to a standardized 9mm depth to reach the targeted bone marrow stemcells (MSC’s). This is three times deeper than comparable microfracture techniques. When tested against an awl or k-wire, NanoFx® resulted in thin, fragmented cancellous bone channels without rotational heat generation. It also demonstrated deep bone perforation with a higher number of open trabecular channels. The regenerative cells are in the bone marrow, the deeper, the better.
>>Learn more about Arthrosurface NanoFx®


nanofactorlogoFlowMembraneNanoFactor™

is nutrient rich amniotic tissue allograft which is obtained from healthy donors who have volunteered to donate their placenta, after undergoing elective caesarian live birth. The Nanofactor™ Flow fluid graft can be applied topically or subcutaneously and can be diluted with preservative free lidocaine or preservative free Marcaine, platelet rich plasma and/or normal saline to a suitable viscosity for in-office delivery. Nanofactor™ Membrane is an is an extracellular matrix derived from human amniotic tissue. It is a regenerative cell-based therapy that can be used in the office or hospital for the management of inflammatory conditions such as tendonitis, joint pain associated with early arthritis and cartilage damage. Amniotic tissue has anti-inflammatory, anti-adhesive, anti-microbial properties and is immunoprivileged while having the inherent advantage of being a time zero graft that is unadulterated by the effects of time.
>>Learn more about Arthrosurface Nanofactor™

NEws / Updates / blog


  • Quick Facts

    • The most common cause of knee pain is osteoarthritis (OA), a degenerative joint disease that causes the cartilage in your joints to break down. When that layer of cartilage — which is meant to “cushion” the joints and protect the surface of the bones — is damaged or worn away, your bones grind against one another, and that grinding hurts. You can feel it climbing stairs, working in the garden, or just bending your knees to sit. It may even keep you up at night.
    • OA can damage the entire knee or be limited to just one side of the knee. If you experience pain only on one side, or compartment, of your knee, your doctor may diagnose you with unicompartmental OA.
    • If you experience knee pain under the knee cap, your doctor may diagnose you with patello-femoral OA. This is not uncommon, as studies have shown that about one out of every 10 patients over the age of 40 have patello-femoral disease.
    • The factors leading to the development and progression of OA include aging, obesity, joint injuries, and a family history of arthritis (genetics). Although there is no cure, early diagnosis and treatment are crucial in slowing or preventing more damage to your joints.
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